A genetic marker for Huntington's chorea.

A genetic register for Huntington's chorea in South Wales.

A regional genetic register for Huntington's chorea in South Wales is described, based on previous family studies in this area, which is one of high prevalence for the disorder. The primary role of the register is to help in the efficient delivery of services, including genetic counselling, to affected subjects and relatives, and to monitor changes in the population at risk. The mode of operati...

Evidence of genetic heterogeneity in Huntington's chorea.

In an extensive study of Huntington's chorea in Queensland evidence was found to support an old observation that the magnitude of the variation in the symptom complex of the disease between different families is sufficient to suggest that there may be more than one form of Huntington's chorea allele present in the community. Analysis of data concerning age at onset indicates that at least two s...

A clinico-genetic study of psychiatric disorder in Huntington's chorea.

The introduction in 1985 of a genetic linkage test programme to identify asymptomatic heterozygotes among subjects at 50% initial risk for Huntington's chorea required a review of all cases of Huntington's chorea and their families referred to the Department of Medical Genetics of the Oxford Regional Health Area (population 2.5 million). From a representative sample of these subjects, psychiatr...

A genetic marker for rheumatic heart disease.

The frequency of antigen types (A, B, C, and DR) in an unselected group of 25 patients with chronic rheumatic heart disease and an unselected group of 15 patients with acute rheumatic fever was compared with that in a group of 100 healthy volunteers. All patients and controls were Arabs of Saudi origin. Only the frequency of HLA-DR4 was significantly different in the controls and the patient gr...

Applying Bioinfomatics Strategies in Huntingtons Disease Research